Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond

BACKGROUND: Single domain antibodies derived from the variable region of the unique heavy chain antibodies found in camelids yield high affinity and regenerable recognition elements. Adding an additional disulfide bond that bridges framework regions is a proven method to increase their melting tempe...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Liu, Jinny L., Goldman, Ellen R., Zabetakis, Dan, Walper, Scott A., Turner, Kendrick B., Shriver-Lake, Lisa C., Anderson, George P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599338/
https://ncbi.nlm.nih.gov/pubmed/26449768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0340-3
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