Experimental evaluation of single‐domain antibodies predicted by molecular dynamics simulations to have elevated thermal stability

Recently Bekker et al. [Bekker G‐J et al. Protein Sci. 2019;28:429–438.] described a computational strategy of applying molecular‐dynamics simulations to estimate the relative stabilities of single‐domain antibodies, and utilized their method to design changes with the aim of increasing the stabilit...

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Udgivet i:Protein Sci
Main Authors: Zabetakis, Dan, Shriver‐Lake, Lisa C., Olson, Mark A., Goldman, Ellen R., Anderson, George P.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2019
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For the Record
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739806/
https://ncbi.nlm.nih.gov/pubmed/31342597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3692
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