Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond

BACKGROUND: Single domain antibodies derived from the variable region of the unique heavy chain antibodies found in camelids yield high affinity and regenerable recognition elements. Adding an additional disulfide bond that bridges framework regions is a proven method to increase their melting tempe...

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Bibliografische gegevens
Gepubliceerd in:Microb Cell Fact
Hoofdauteurs: Liu, Jinny L., Goldman, Ellen R., Zabetakis, Dan, Walper, Scott A., Turner, Kendrick B., Shriver-Lake, Lisa C., Anderson, George P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599338/
https://ncbi.nlm.nih.gov/pubmed/26449768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0340-3
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