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Gα(13) Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets
Even though GPCR signaling in human platelets is directly involved in hemostasis and thrombus formation, the sequence of events by which G protein activation leads to αIIbβ3 integrin activation (inside-out signaling) is not clearly defined. We previously demonstrated that a conformationally sensitiv...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599016/ https://ncbi.nlm.nih.gov/pubmed/26292217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650978 |
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