Gα(13) Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin

Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in quiescent cells. Talin is a large 235-kDa protein com...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Schiemer, James, Bohm, Andrew, Lin, Li, Merrill-Skoloff, Glenn, Flaumenhaft, Robert, Huang, Jin-Sheng, Le Breton, Guy C., Chishti, Athar H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207171/
https://ncbi.nlm.nih.gov/pubmed/27803165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747279
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker