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Gα(13) Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin
Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in quiescent cells. Talin is a large 235-kDa protein com...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular
Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207171/ https://ncbi.nlm.nih.gov/pubmed/27803165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747279 |
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