Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism

Pancreatic islet failure, involving loss of glucose-stimulated insulin secretion (GSIS) from islet β-cells, heralds the onset of type 2 diabetes (T2D). To search for mediators of GSIS, we performed metabolomics profiling of the insulinoma cell line 832/13, and uncovered significant glucose-induced c...

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Foilsithe in:Cell Rep
Main Authors: Gooding, Jessica R., Jensen, Mette V., Dai, Xiaoqing, Wenner, Brett R., Lu, Danhong, Arumugam, Ramamani, Ferdaoussi, Mourad, MacDonald, Patrick E., Newgard, Christopher B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598307/
https://ncbi.nlm.nih.gov/pubmed/26411681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.072
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