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Differential and Complementary Effects of Glucose and Prolactin on Islet DNA Synthesis and Gene Expression

The mechanisms by which lactogenic hormones promote β-cell expansion remain poorly understood. Because prolactin (PRL) up-regulates β-cell glucose transporter 2, glucokinase, and pyruvate dehydrogenase activities, we reasoned that glucose availability might mediate or modulate the effects of PRL on...

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Autors principals: Arumugam, Ramamani, Fleenor, Donald, Lu, Danhong, Freemark, Michael
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198965/
https://ncbi.nlm.nih.gov/pubmed/21239441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1258
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