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Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression
BACKGROUND: Prolactin (PRL) and placental lactogen stimulate beta cell replication and insulin production in vitro and in vivo. The molecular mechanisms by which lactogens promote beta cell expansion are unclear. METHODS: We treated rat insulinoma cells with a PRL receptor (PRLR) siRNA to determine...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984618/ https://ncbi.nlm.nih.gov/pubmed/24114406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-013-0073-1 |
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