Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses

Tumor antigen-specific CD4(+) T cells generally orchestrate and regulate immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4(+) T cells is restricted at local tumor sites where antigen-presenting cells (APCs) are frequently dysfunctional, which...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Matsuzaki, Junko, Tsuji, Takemasa, Luescher, Immanuel F., Shiku, Hiroshi, Mineno, Junichi, Okamoto, Sachiko, Old, Lloyd J., Shrikant, Protul, Gnjatic, Sacha, Odunsi, Kunle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597193/
https://ncbi.nlm.nih.gov/pubmed/26447332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14896
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