Colon tumors with the simultaneous induction of driver mutations in APC, KRAS, and PIK3CA still progress through the adenoma-to-carcinoma sequence

Human colorectal cancers often possess multiple mutations, including 3–6 driver mutations per tumor. The timing of when these mutations occur during tumor development and progression continues to be debated. More advanced lesions carry a greater number of driver mutations, indicating that colon tumo...

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Pubblicato in:Cancer Prev Res (Phila)
Autori principali: Hadac, Jamie N., Leystra, Alyssa A., Olson, Terrah J. Paul, Maher, Molly E., Payne, Susan N, Yueh, Alexander E., Schwartz, Alexander R., Albrecht, Dawn M., Clipson, Linda, Pasch, Cheri A., Matkowskyj, Kristina A., Halberg, Richard B., Deming, Dustin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596777/
https://ncbi.nlm.nih.gov/pubmed/26276752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0003
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