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Increased Fab thermoresistance via V(H)-targeted directed evolution
Antibody aggregation is frequently mediated by the complementarity determining regions within the variable domains and can significantly decrease purification yields, shorten shelf-life and increase the risk of anti-drug immune responses. Aggregation-resistant antibodies could offset these risks; ac...
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| Publicado en: | Protein Eng Des Sel |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4596279/ https://ncbi.nlm.nih.gov/pubmed/26283664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv037 |
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