Increased Fab thermoresistance via V(H)-targeted directed evolution

Antibody aggregation is frequently mediated by the complementarity determining regions within the variable domains and can significantly decrease purification yields, shorten shelf-life and increase the risk of anti-drug immune responses. Aggregation-resistant antibodies could offset these risks; ac...

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Bibliographic Details
Published in:Protein Eng Des Sel
Main Authors: Entzminger, Kevin C., Johnson, Jennifer L., Hyun, Jeongmin, Lieberman, Raquel L., Maynard, Jennifer A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Single Domain Antibodies, Libraries and Innovations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596279/
https://ncbi.nlm.nih.gov/pubmed/26283664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv037
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