Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments

Protein crystallization is dependent upon, and sensitive to, the intermolecular contacts that assist in ordering proteins into a three dimensional lattice. Here we used protein engineering and mutagenesis to affect the crystallization of single chain antibody fragments (scFvs) that recognize the EE...

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Hlavní autoři: Kalyoncu, Sibel, Hyun, Jeongmin, Pai, Jennifer C., Johnson, Jennifer L., Entzminger, Kevin, Jain, Avni, Heaner, David P., Morales, Ivan A., Truskett, Thomas M., Maynard, Jennifer A., Lieberman, Raquel L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142072/
https://ncbi.nlm.nih.gov/pubmed/24615866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24542
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