Telomere dysfunction drives aberrant hematopoietic differentiation and Myelodysplastic Syndrome

Myelodysplastic syndrome (MDS) risk correlates with advancing age, therapy-induced DNA damage, and/or shorter telomeres but whether telomere erosion directly induces MDS is unknown. Here, we provide the genetic evidence that telomere dysfunction-induced DNA damage drives classical MDS phenotypes and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Colla, Simona, Ong, Derrick Sek Tong, Ogoti, Yamini, Marchesini, Matteo, Mistry, Nipun A., Clise-Dwyer, Karen, Ang, Sonny A., Storti, Paola, Viale, Andrea, Giuliani, Nicola, Ruisaard, Kathryn, Gomez, Irene Ganan, Bristow, Christopher A., Estecio, Marcos, Weksberg, David C., Ho, Yan Wing, Hu, Baoli, Genovese, Giannicola, Pettazzoni, Piergiorgio, Multani, Asha S., Jiang, Shan, Hua, Sujun, Ryan, Michael C., Carugo, Alessandro, Nezi, Luigi, Wei, Yue, Yang, Hui, D’Anca, Marianna, Zhang, Li, Gaddis, Sarah, Gong, Ting, Horner, James W., Heffernan, Timothy P., Jones, Philip, Cooper, Laurence J.N., Liang, Han, Kantarjian, Hagop, Wang, Y. Alan, Chin, Lynda, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596059/
https://ncbi.nlm.nih.gov/pubmed/25965571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.04.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados