PAF promotes stemness and radioresistance of glioma stem cells

An integrated genomic and functional analysis to elucidate DNA damage signaling factors promoting self-renewal of glioma stem cells (GSCs) identified proliferating cell nuclear antigen (PCNA)-associated factor (PAF) up-regulation in glioblastoma. PAF is preferentially overexpressed in GSCs. Its depl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ong, Derrick Sek Tong, Hu, Baoli, Ho, Yan Wing, Sauvé, Charles-Etienne Gabriel, Bristow, Christopher A., Wang, Qianghu, Multani, Asha S., Chen, Peiwen, Nezi, Luigi, Jiang, Shan, Gorman, Claire Elizabeth, Monasterio, Marta Moreno, Koul, Dimpy, Marchesini, Matteo, Colla, Simona, Jin, Eun-Jung, Sulman, Erik P., Spring, Denise J., Yung, Wai-Kwan Alfred, Verhaak, Roel G. W., Chin, Lynda, Wang, Y. Alan, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664518/
https://ncbi.nlm.nih.gov/pubmed/29073105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708122114
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