Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

Mutated KRAS (KRAS*) is a fundamental driver in the majority of pancreatic ductal adenocarcinomas (PDAC). Using an inducible mouse model of KRAS*-driven PDAC, we compared KRAS* genetic extinction to pharmacological inhibition of MEK1 in tumor spheres and in vivo. KRAS* ablation blocked proliferation...

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Foilsithe in:Cancer Res
Main Authors: Pettazzoni, Piergiorgio, Viale, Andrea, Shah, Parantu, Carugo, Alessandro, Ying, Haoqiang, Wang, Huamin, Genovese, Giannicola, Seth, Sahil, Minelli, Rosalba, Green, Tessa, Huang-Hobbs, Emmet, Corti, Denise, Sanchez, Nora, Nezi, Luigi, Marchesini, Matteo, Kapoor, Avnish, Yao, Wantong, Di Francesco, Maria Emilia, Petrocchi, Alessia, Deem, Angela K., Scott, Kenneth, Colla, Simona, Mills, Gordon B., Fleming, Jason B., Heffernan, Timothy P., Jones, Philip, Toniatti, Carlo, DePinho, Ronald A., Draetta, Giulio F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446709/
https://ncbi.nlm.nih.gov/pubmed/25736685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1854
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