MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

MDM2 (mouse double minute 2) inhibitors that activate p53 and induce apoptosis in a non-genotoxic manner are in clinical development for treatment of leukemias. P53 can modulate other programmed cell death pathways including autophagy both transcriptionally and non-transcriptionally. We investigated...

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Publicat a:PLoS One
Autors principals: Borthakur, Gautam, Duvvuri, Seshagiri, Ruvolo, Vivian, Tripathi, Durga Nand, Piya, Sujan, Burks, Jared, Jacamo, Rodrigo, Kojima, Kensuke, Ruvolo, Peter, Fueyo-Margareto, Juan, Konopleva, Marina, Andreeff, Michael
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595506/
https://ncbi.nlm.nih.gov/pubmed/26440941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139254
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