The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves...

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Publicat a:PLoS One
Autors principals: Wong, Deysi V. T., Lima-Júnior, Roberto C. P., Carvalho, Cibele B. M., Borges, Vanessa F., Wanderley, Carlos W. S., Bem, Amanda X. C., Leite, Caio A. V. G., Teixeira, Maraiza A., Batista, Gabriela L. P., Silva, Rangel L., Cunha, Thiago M., Brito, Gerly A. C., Almeida, Paulo R. C., Cunha, Fernando Q., Ribeiro, Ronaldo A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595146/
https://ncbi.nlm.nih.gov/pubmed/26440613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139985
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