The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Wong, Deysi V. T., Lima-Júnior, Roberto C. P., Carvalho, Cibele B. M., Borges, Vanessa F., Wanderley, Carlos W. S., Bem, Amanda X. C., Leite, Caio A. V. G., Teixeira, Maraiza A., Batista, Gabriela L. P., Silva, Rangel L., Cunha, Thiago M., Brito, Gerly A. C., Almeida, Paulo R. C., Cunha, Fernando Q., Ribeiro, Ronaldo A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595146/
https://ncbi.nlm.nih.gov/pubmed/26440613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139985
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