The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Wong, Deysi V. T., Lima-Júnior, Roberto C. P., Carvalho, Cibele B. M., Borges, Vanessa F., Wanderley, Carlos W. S., Bem, Amanda X. C., Leite, Caio A. V. G., Teixeira, Maraiza A., Batista, Gabriela L. P., Silva, Rangel L., Cunha, Thiago M., Brito, Gerly A. C., Almeida, Paulo R. C., Cunha, Fernando Q., Ribeiro, Ronaldo A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595146/
https://ncbi.nlm.nih.gov/pubmed/26440613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139985
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