MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T cells Promotes Mucosal Tolerance and Enforces Commensalism

Commensal microbiota promote mucosal tolerance in part by engaging regulatory T (Treg) cells via Toll like receptors (TLR). We report that Treg cell-specific deletion of the TLR adaptor MyD88 resulted in deficiency of intestinal Treg cells, a reciprocal increase in T helper-17 (Th17) cells and heigh...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Wang, Sen, Charbonnier, Louis-Marie, Rivas, Magali Noval, Georgiev, Peter, Li, Ning, Gerber, Georg, Bry, Lynn, Chatila, Talal A
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545404/
https://ncbi.nlm.nih.gov/pubmed/26231118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.014
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