MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T cells Promotes Mucosal Tolerance and Enforces Commensalism

Commensal microbiota promote mucosal tolerance in part by engaging regulatory T (Treg) cells via Toll like receptors (TLR). We report that Treg cell-specific deletion of the TLR adaptor MyD88 resulted in deficiency of intestinal Treg cells, a reciprocal increase in T helper-17 (Th17) cells and heigh...

Full description

Saved in:
Bibliographic Details
Published in:Immunity
Main Authors: Wang, Sen, Charbonnier, Louis-Marie, Rivas, Magali Noval, Georgiev, Peter, Li, Ning, Gerber, Georg, Bry, Lynn, Chatila, Talal A
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545404/
https://ncbi.nlm.nih.gov/pubmed/26231118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.014
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items