Microbiota Therapy Acts Via a Regulatory T Cell MyD88/RORγt Pathway to Suppress Food Allergy

The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice. Infants and mice with FA had decreased IgA and increased IgE binding to fecal bacteria, indicative of a broad...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Abdel-Gadir, Azza, Stephen-Victor, Emmanuel, Gerber, Georg K., Rivas, Magali Noval, Wang, Sen, Harb, Hani, Wang, Leighanne, Li, Ning, Crestani, Elena, Spielman, Sara, Secor, William, Biehl, Heather, Dibendetto, Nicholas, Dong, Xiaoxi, Umetsu, Dale T., Bry, Lynn, Rachid, Rima, Chatila, Talal A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677395/
https://ncbi.nlm.nih.gov/pubmed/31235962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0461-z
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