MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice

Tregs expressing the transcription factor Foxp3 suppress self-reactive T cells, prevent autoimmunity, and help contain immune responses to foreign antigens, thereby limiting the potential for inadvertent tissue damage. Mutations in the FOXP3 gene result in Treg deficiency in mice and humans, which l...

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Hlavní autoři: Rivas, Magali Noval, Koh, Yi T., Chen, Andrew, Nguyen, Annie, Lee, Young Ho, Lawson, Greg, Chatila, Talal A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336968/
https://ncbi.nlm.nih.gov/pubmed/22466646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40591
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