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DOCK8 functions as an adaptor that links Toll-like receptor–MyD88 signaling to B cell activation
DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27(+) memory B cells were severely reduced in DOCK8-deficient patients. Toll-like receptor 9 (TLR9)- but not CD40-driven B cell proliferation and immunoglobulin production were severely re...
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362684/ https://ncbi.nlm.nih.gov/pubmed/22581261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2305 |
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