DOCK8 functions as an adaptor that links Toll-like receptor–MyD88 signaling to B cell activation

DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27(+) memory B cells were severely reduced in DOCK8-deficient patients. Toll-like receptor 9 (TLR9)- but not CD40-driven B cell proliferation and immunoglobulin production were severely re...

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Główni autorzy: Jabara, Haifa H., McDonald, Douglas R., Janssen, Erin, Massaad, Michel J., Ramesh, Narayanaswamy, Borzutzky, Arturo, Rauter, Ingrid, Benson, Halli, Schneider, Lynda, Baxi, Sachin, Recher, Mike, Notarangelo, Luigi, Wakim, Rima, Dbaibo, Ghassan, Dasouki, Majed, Al-Herz, Waleed, Barlan, Isil, Baris, Safa, Kutukculer, Necil, Ochs, Hans, Plebani, Alessandro, Kanariou, Maria, Lefranc, Gerard, Reisli, Ismail, Fitzgerald, Kate, Golenbock, Douglas, Manis, John, Keles, Sevgi, Ceja, Reuben, Chatila, Talal, Geha, Raif S.
Format: Artigo
Język:Inglês
Wydane: 2012
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362684/
https://ncbi.nlm.nih.gov/pubmed/22581261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2305
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