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Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria

AIMS: The aim was to investigate the QT effect of a single dose combination regimen of piperaquine phosphate (PQP) and a novel aromatic trioxolane, OZ439, for malaria treatment. METHODS: Exposure–response (ER) analysis was performed on data from a placebo-controlled, single dose, study with OZ439 an...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Darpo, Borje, Ferber, Georg, Siegl, Peter, Laurijssens, Bart, Macintyre, Fiona, Toovey, Stephen, Duparc, Stephan
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594707/
https://ncbi.nlm.nih.gov/pubmed/25966781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12680
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