The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2

In the present study, we investigated the potential activity of OSI-027, a potent and selective mammalian target of rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor, against pancreatic cancer cells both in vitro and in vivo. We demonstrated that OSI-027 inhibited survival and growth of both pr...

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Dades bibliogràfiques
Publicat a:DNA Cell Biol
Autors principals: Chen, Bo, Xu, Ming, Zhang, Hui, Xu, Ming-zheng, Wang, Xu-jing, Tang, Qing-he, Tang, Jian-ying
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Original Research ArticlesOrganelles/Autophagy/Apoptosis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593879/
https://ncbi.nlm.nih.gov/pubmed/26284306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2015.2886
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