Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly and is characterized by memory loss and cognitive decline. Pathological hallmark of AD brains are intracellular neurofibrillary tangles and extracellular amyloid plaques. The major component of these plaques is the highly heter...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Dammers, Christina, Gremer, Lothar, Neudecker, Philipp, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593648/
https://ncbi.nlm.nih.gov/pubmed/26436664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139710
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