Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly and is characterized by memory loss and cognitive decline. Pathological hallmark of AD brains are intracellular neurofibrillary tangles and extracellular amyloid plaques. The major component of these plaques is the highly heter...

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Bibliographic Details
Published in:PLoS One
Main Authors: Dammers, Christina, Gremer, Lothar, Neudecker, Philipp, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593648/
https://ncbi.nlm.nih.gov/pubmed/26436664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139710
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