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Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain
Rhodesain, the major cathepsin L-like cysteine protease in the protozoan Trypanosoma brucei rhodesiense, the causative agent of African sleeping sickness, is a well-validated drug target. In this work, we used a fragment-based approach to identify inhibitors of this cysteine protease, and identified...
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| Izdano u: | Bioorg Med Chem Lett |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4592840/ https://ncbi.nlm.nih.gov/pubmed/26342866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.074 |
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