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Vinyl Sulfone-based Inhibitors of Trypanosomal Cysteine Protease Rhodesain with Improved Antitrypanosomal Activities

The number of reported cases of Human African Trypanosmiasis (HAT), caused by kinetoplastid protozoan parasite Trypanosoma brucei, is declining in sub-Saharan Africa. Historically, such declines are generally followed by periods of higher incidence, and one of the lingering public health challenges...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Zhang, Huaisheng, Collins, Jasmine, Nyamwihura, Rogers, Crown, Olamide, Ajayi, Oluwatomi, Ogungbe, Ifedayo Victor
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305937/
https://ncbi.nlm.nih.gov/pubmed/32527539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127217
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