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Discovery of a Quinoline-Based Phenyl Sulfone Derivative as an Antitrypanosomal Agent

A series of natural products-based phenyl sulfone derivative and their property-based analogues were investigated as potential growth inhibitors of Trypanosoma brucei. Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, we found that nopol- and quinoli...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Zhang, Huaisheng, Collins, Jasmine, Nyamwihura, Rogers, Ware, Shelbi, Kaiser, Marcel, Ogungbe, Ifedayo Victor
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912169/
https://ncbi.nlm.nih.gov/pubmed/29609908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.039
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