Parkin Regulates Mitosis and Genomic Stability Through Cdc20/Cdh1

Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) co-activators Cdc20 and Cdh1 to medi...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lee, Seung Baek, Kim, Jung Jin, Nam, Hyun-Ja, Gao, Bowen, Yin, Ping, Qin, Bo, Yi, Sang-Yeop, Ham, Hyoungjun, Evans, Debra, Kim, Sun-Hyun, Zhang, Jun, Deng, Min, Liu, Tongzheng, Zhang, Haoxing, Billadeau, Daniel D., Wang, Liewei, Giaime, Emilie, Shen, Jie, Pang, Yuan-Ping, Jen, Jin, van Deursen, Jan M., Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592523/
https://ncbi.nlm.nih.gov/pubmed/26387737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.011
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