Parkin Regulates Mitosis and Genomic Stability Through Cdc20/Cdh1

Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) co-activators Cdc20 and Cdh1 to medi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Lee, Seung Baek, Kim, Jung Jin, Nam, Hyun-Ja, Gao, Bowen, Yin, Ping, Qin, Bo, Yi, Sang-Yeop, Ham, Hyoungjun, Evans, Debra, Kim, Sun-Hyun, Zhang, Jun, Deng, Min, Liu, Tongzheng, Zhang, Haoxing, Billadeau, Daniel D., Wang, Liewei, Giaime, Emilie, Shen, Jie, Pang, Yuan-Ping, Jen, Jin, van Deursen, Jan M., Lou, Zhenkun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592523/
https://ncbi.nlm.nih.gov/pubmed/26387737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.011
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