Parkin Regulates Mitosis and Genomic Stability Through Cdc20/Cdh1

Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) co-activators Cdc20 and Cdh1 to medi...

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Pubblicato in:Mol Cell
Autori principali: Lee, Seung Baek, Kim, Jung Jin, Nam, Hyun-Ja, Gao, Bowen, Yin, Ping, Qin, Bo, Yi, Sang-Yeop, Ham, Hyoungjun, Evans, Debra, Kim, Sun-Hyun, Zhang, Jun, Deng, Min, Liu, Tongzheng, Zhang, Haoxing, Billadeau, Daniel D., Wang, Liewei, Giaime, Emilie, Shen, Jie, Pang, Yuan-Ping, Jen, Jin, van Deursen, Jan M., Lou, Zhenkun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592523/
https://ncbi.nlm.nih.gov/pubmed/26387737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.011
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