Piperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins

Elevated plasma low-density lipoprotein (LDL) cholesterol is considered as a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) uptakes plasma lipoproteins and lowers plasma LDL cholesterol, the activation of LDLR is a promising drug target for atherosclerosis. In the present s...

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Vydáno v:PLoS One
Hlavní autoři: Ochiai, Ayasa, Miyata, Shingo, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592265/
https://ncbi.nlm.nih.gov/pubmed/26431033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139799
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