Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

Sterol regulatory element-binding proteins (SREBPs) are the key transcription factors that modulate lipid biosynthesis. SREBPs are synthesized as endoplasmic reticulum-bound precursors that require proteolytic activation in the Golgi apparatus. The stability and maturation of precursor SREBPs depend...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kuan, Yen-Chou, Hashidume, Tsutomu, Shibata, Takahiro, Uchida, Koji, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314195/
https://ncbi.nlm.nih.gov/pubmed/28003358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.767277
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