Ring finger protein 5 activates sterol regulatory element–binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP

Sterol regulatory element–binding protein 2 (SREBP2) is the master transcription factor that regulates cholesterol metabolism. SREBP2 activation is regulated by SREBP chaperone SCAP. Here we show that ring finger protein 5 (RNF5), an endoplasmic reticulum-anchored E3 ubiquitin ligase, mediates the L...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kuan, Yen-Chou, Takahashi, Yu, Maruyama, Takashi, Shimizu, Makoto, Yamauchi, Yoshio, Sato, Ryuichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086040/
https://ncbi.nlm.nih.gov/pubmed/32054686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011849
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