Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Arnold, Laurence H., Groom, Harriet C. T., Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J., Ordonez, Paula, Mann, Melanie C., Rueschenbaum, Sabrina, Goldstone, David C., Pennell, Simon, Howell, Steven A., Stoye, Jonathan P., Webb, Michelle, Taylor, Ian A., Bishop, Kate N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://ncbi.nlm.nih.gov/pubmed/26431200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005194
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