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Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction
SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...
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| Publicado en: | PLoS Pathog |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4592219/ https://ncbi.nlm.nih.gov/pubmed/26431200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005194 |
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