Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Arnold, Laurence H., Groom, Harriet C. T., Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J., Ordonez, Paula, Mann, Melanie C., Rueschenbaum, Sabrina, Goldstone, David C., Pennell, Simon, Howell, Steven A., Stoye, Jonathan P., Webb, Michelle, Taylor, Ian A., Bishop, Kate N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://ncbi.nlm.nih.gov/pubmed/26431200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005194
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