Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:PLoS Pathog
Glavni autori: Arnold, Laurence H., Groom, Harriet C. T., Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J., Ordonez, Paula, Mann, Melanie C., Rueschenbaum, Sabrina, Goldstone, David C., Pennell, Simon, Howell, Steven A., Stoye, Jonathan P., Webb, Michelle, Taylor, Ian A., Bishop, Kate N.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://ncbi.nlm.nih.gov/pubmed/26431200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005194
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items