SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells

SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate. In myeloid-derived dendritic cells and macrophages as well as resting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydrolase activity...

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Publicado en:Sci Rep
Autores principales: Ordonez, Paula, Kunzelmann, Simone, Groom, Harriet C. T., Yap, Melvyn W., Weising, Simon, Meier, Chris, Bishop, Kate N., Taylor, Ian A., Stoye, Jonathan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318888/
https://ncbi.nlm.nih.gov/pubmed/28220857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42824
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