Structural basis of lentiviral subversion of a cellular protein degradation pathway

Lentiviruses contain accessory genes that have evolved to counteract the effects of host cellular defence proteins that inhibit productive infection. One such restriction factor, SAMHD1, inhibits HIV-1 infection of myeloid-lineage cells (1,2) as well as resting CD4(+) T cells (3,4) by reducing the c...

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Bibliografiske detaljer
Main Authors: Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886899/
https://ncbi.nlm.nih.gov/pubmed/24336198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12815
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