Structural basis of lentiviral subversion of a cellular protein degradation pathway

Lentiviruses contain accessory genes that have evolved to counteract the effects of host cellular defence proteins that inhibit productive infection. One such restriction factor, SAMHD1, inhibits HIV-1 infection of myeloid-lineage cells (1,2) as well as resting CD4(+) T cells (3,4) by reducing the c...

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Bibliographic Details
Main Authors:	Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3886899/ https://ncbi.nlm.nih.gov/pubmed/24336198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12815
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Structural basis of lentiviral subversion of a cellular protein degradation pathway

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