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Structural basis of lentiviral subversion of a cellular protein degradation pathway
Lentiviruses contain accessory genes that have evolved to counteract the effects of host cellular defence proteins that inhibit productive infection. One such restriction factor, SAMHD1, inhibits HIV-1 infection of myeloid-lineage cells (1,2) as well as resting CD4(+) T cells (3,4) by reducing the c...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3886899/ https://ncbi.nlm.nih.gov/pubmed/24336198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12815 |
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