Structural basis of lentiviral subversion of a cellular protein degradation pathway

Lentiviruses contain accessory genes that have evolved to counteract the effects of host cellular defence proteins that inhibit productive infection. One such restriction factor, SAMHD1, inhibits HIV-1 infection of myeloid-lineage cells (1,2) as well as resting CD4(+) T cells (3,4) by reducing the c...

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Detaylı Bibliyografya
Asıl Yazarlar: Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886899/
https://ncbi.nlm.nih.gov/pubmed/24336198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12815
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