Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...

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Publicat a:PLoS Pathog
Autors principals: Arnold, Laurence H., Groom, Harriet C. T., Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J., Ordonez, Paula, Mann, Melanie C., Rueschenbaum, Sabrina, Goldstone, David C., Pennell, Simon, Howell, Steven A., Stoye, Jonathan P., Webb, Michelle, Taylor, Ian A., Bishop, Kate N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://ncbi.nlm.nih.gov/pubmed/26431200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005194
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