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Saturated Fatty Acids Induce Post-transcriptional Regulation of HAMP mRNA via AU-rich Element-binding Protein, Human Antigen R (HuR)

Iron is implicated in fatty liver disease pathogenesis. The human hepcidin gene, HAMP, is the master switch of iron metabolism. The aim of this study is to investigate the regulation of HAMP expression by fatty acids in HepG2 cells. For these studies, both saturated fatty acids (palmitic acid (PA) a...

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Pubblicato in:J Biol Chem
Autori principali: Lu, Sizhao, Mott, Justin L., Harrison-Findik, Duygu Dee
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591806/
https://ncbi.nlm.nih.gov/pubmed/26304124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648212
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