Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST

BACKGROUND: X-chromosome inactivation is a striking example of epigenetic silencing in which expression of the long non-coding RNA XIST initiates the heterochromatinization and silencing of one of the pair of X chromosomes in mammalian females. To understand how the RNA can establish silencing acros...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Kelsey, Angela D., Yang, Christine, Leung, Danny, Minks, Jakub, Dixon-McDougall, Thomas, Baldry, Sarah E.L., Bogutz, Aaron B., Lefebvre, Louis, Brown, Carolyn J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591629/
https://ncbi.nlm.nih.gov/pubmed/26429547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0774-2
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