XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells

BACKGROUND: The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis...

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Hlavní autoři: Minks, Jakub, Baldry, Sarah EL, Yang, Christine, Cotton, Allison M, Brown, Carolyn J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734131/
https://ncbi.nlm.nih.gov/pubmed/23915978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-23
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