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XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
BACKGROUND: The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3734131/ https://ncbi.nlm.nih.gov/pubmed/23915978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-23 |
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