Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner

Mechanistic target of rapamycin (serine/threonine kinase) complex 1 (MTORC1) is a protein-signaling complex at the fulcrum of anabolic and catabolic processes, which acts depending on wide-ranging environmental cues. It is generally accepted that lysosomes facilitate MTORC1 activation by generating...

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Detalles Bibliográficos
Publicado en:Autophagy
Main Authors: Newton, Phillip T, Vuppalapati, Karuna K, Bouderlique, Thibault, Chagin, Andrei S
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
Assuntos:
Basic Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590675/
https://ncbi.nlm.nih.gov/pubmed/26259639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1068489
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