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Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications 2016, 7:11151). Both laboratories employed TS...

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Библиографические подробности
Опубликовано в: :Bone Rep
Главные авторы: Newton, Phillip T., Xie, Meng, Medvedeva, Ekaterina V., Sävendahl, Lars, Chagin, Andrei S.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020113/
https://ncbi.nlm.nih.gov/pubmed/29955624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2018.02.006
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