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Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications 2016, 7:11151). Both laboratories employed TS...

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Detalhes bibliográficos
Publicado no:Bone Rep
Main Authors: Newton, Phillip T., Xie, Meng, Medvedeva, Ekaterina V., Sävendahl, Lars, Chagin, Andrei S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020113/
https://ncbi.nlm.nih.gov/pubmed/29955624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2018.02.006
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